The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2009
Filed:
Dec. 17, 2007
Patrick G. Harran, Dallas, TX (US);
Xiaodong Wang, Dallas, TX (US);
Jef K. DE Brabander, Dallas, TX (US);
Lin LI, Dallas, TX (US);
Ranny Mathew Thomas, Dallas, TX (US);
Hidetaka Suzuki, Dallas, TX (US);
Patrick G. Harran, Dallas, TX (US);
Xiaodong Wang, Dallas, TX (US);
Jef K. De Brabander, Dallas, TX (US);
Lin Li, Dallas, TX (US);
Ranny Mathew Thomas, Dallas, TX (US);
Hidetaka Suzuki, Dallas, TX (US);
Board of Regents, The University of Texas System, Austin, TX (US);
Abstract
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.