The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 29, 2009
Filed:
Jan. 19, 2006
Paul L. Hallenbeck, Chester Springs, PA (US);
Seshidar Reddy Police, Chester Springs, PA (US);
Laura M. Hales, Chester Springs, PA (US);
Carl M. Hay, Damascus, MD (US);
Shanthi Ganesh, San Francisco, CA (US);
Ling Xu, Boyds, MD (US);
Jingping Yang, Gaithersburg, MD (US);
Cheng Cheng, Rockville, MD (US);
Paul L. Hallenbeck, Chester Springs, PA (US);
Seshidar Reddy Police, Chester Springs, PA (US);
Laura M. Hales, Chester Springs, PA (US);
Carl M. Hay, Damascus, MD (US);
Shanthi Ganesh, San Francisco, CA (US);
Ling Xu, Boyds, MD (US);
Jingping Yang, Gaithersburg, MD (US);
Cheng Cheng, Rockville, MD (US);
Norvartis AG, Basel, CH;
Abstract
The present invention relates to a novel RNAthat is called Seneca Valley virus ('SVV'). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids. Further, the invention provides antibodies that are raised against the SVV proteins. Because SVV has the ability to selectively kill some types of tumors, the invention provides methods of using SVV and SVV polypeptides to treat cancer. Because SVV specifically targets certain tumors, the invention provides methods of using SVV nucleic acids and proteins to detect cancer. Additionally, due to the information provided by the tumor-specific mechanisms of SVV, the invention provides methods of making new oncolytic virus derivatives and of altering viruses to have tumor-specific tropisms.