The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 2009
Filed:
Oct. 05, 2006
Bomie Han, Carmel, IN (US);
Andrew Korytko, Oceanside, CA (US);
Pamela Jean Mitchell, Indianapolis, IN (US);
Linda O'bryan, Indianapolis, IN (US);
Rong Wang, Carmel, IN (US);
Rosamund Carol Smith, Greenfield, IN (US);
Bomie Han, Carmel, IN (US);
Andrew Korytko, Oceanside, CA (US);
Pamela Jean Mitchell, Indianapolis, IN (US);
Linda O'Bryan, Indianapolis, IN (US);
Rong Wang, Carmel, IN (US);
Rosamund Carol Smith, Greenfield, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.