The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 2009
Filed:
Sep. 03, 2004
Samuel J. Danishefsky, Englewood, NJ (US);
J. David Warren, New York, NY (US);
Samuel J. Danishefsky, Englewood, NJ (US);
J. David Warren, New York, NY (US);
Sloan-Kettering Institute For Cancer Research, New York, NY (US);
Abstract
The present invention provides a method for preparing polyfunctionalized peptides and/or proteins at non-adjacent designated sites via native chemical ligation. In certain embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently subsituted with a moiety having the structure: wherein A and Lare as defined herein. In certain other embodiments, the inventive method allows the preparation of polyfunctionalized peptides having the general structure: wherein A, R, R, P, R, L, to, s, t and q are as defined herein.