The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 2009
Filed:
Nov. 25, 2005
José Ignacio Andrés-gil, Madrid, ES;
José Manuel Bartolomé-nebreda, Toledo, ES;
Manuel Jesus Alcázar-vaca, Toledo, ES;
Maria DE Las Mercedes Garcia-martin, Madrid, ES;
Antonius Adrianus Hendrikus Petrus Megens, Beerse, BE;
José Ignacio Andrés-Gil, Madrid, ES;
José Manuel Bartolomé-Nebreda, Toledo, ES;
Manuel Jesus Alcázar-Vaca, Toledo, ES;
Maria de las Mercedes Garcia-Martin, Madrid, ES;
Antonius Adrianus Hendrikus Petrus Megens, Beerse, BE;
Janssen Pharmaceutica N.V., Beerse, BE;
Abstract
The present invention relates to novel isoxazoline-indole derivatives according to Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, with a binding affinity towards dopamine receptors, in particular towards dopamine Dand/or Dreceptors, with selective serotonin reuptake inhibition (SSRI) properties and showing an affinity for the 5-HTreceptor, pharmaceutical compositions comprising the compounds according to the invention, the use thereof for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic disorders, most in particular schizophrenia and processes for their production, wherein the variables are further defined in the application.