The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 2009
Filed:
Sep. 20, 2007
Walter Newman, Boston, MA (US);
Shixin Qin, Lexington, MA (US);
Theresa L. O'keefe, Waltham, MA (US);
Robert A. Obar, Walpole, MA (US);
Walter Newman, Boston, MA (US);
Shixin Qin, Lexington, MA (US);
Theresa L. O'Keefe, Waltham, MA (US);
Robert A. Obar, Walpole, MA (US);
Cornerstone Therapeutics, Inc., Cary, NC (US);
Abstract
In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of an inflammatory cytokine cascade and methods of detecting an HMGB polypeptide in a sample.