The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2009
Filed:
Oct. 24, 2008
Bandi Parthasaradhi Reddy, Andhrapradesh, IN;
Kura Rathnakar Reddy, Andhrapradesh, IN;
Rapolu Raji Reddy, Andhrapradesh, IN;
Dasari Muralidhara Reddy, Andhrapradesh, IN;
Nagabelli Murali, Hyderabad Andhrapradesh, IN;
Bandi Parthasaradhi Reddy, Andhrapradesh, IN;
Kura Rathnakar Reddy, Andhrapradesh, IN;
Rapolu Raji Reddy, Andhrapradesh, IN;
Dasari Muralidhara Reddy, Andhrapradesh, IN;
Nagabelli Murali, Hyderabad Andhrapradesh, IN;
Hetero Drugs Limited, , IN;
Abstract
The present invention relates to a process for preparing a key intermediate of cefprozil and use of this intermediate in the preparation of cefprozil thereby avoiding impurity-causing self-acylation. [R-(Z)]-[4-hydroxy-α-[(3-methoxy-1-methyl-3-oxo-1-propenyl)amino]] benzeneacetic acid, mono potassium salt is reacted with ethyl chloroformate to obtain mixed anhydride which is then silylated with N,O-bis(trimethylsilyl)acetamide. The silylated compound obtained is reacted with [7-trimethylsilylamino-3-(Z/E-propen-1-yl)-3-cephem-4-carboxylic acid]trimethylsilyl ester and deprotected with aqueous hydrochloric acid to give cefprozil.