The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2009
Filed:
Jul. 01, 2005
Kevin R. Campos, Berkeley Heights, NJ (US);
Artis Klapars, Scotch Plains, NJ (US);
J. Christopher Mcwilliams, Hoboken, NJ (US);
C. Scott Shultz, Maplewood, NJ (US);
Debra J. Wallace, Scotch Plains, NJ (US);
Alex M. Chen, Metuchen, NJ (US);
Lisa F. Frey, Somerset, NJ (US);
Andrey V. Peresypkin, Cranford, NJ (US);
Yaling Wang, Westfield, NJ (US);
Robert M. Wenslow, Cream Ridge, NJ (US);
Cheng-yi Chen, Plainsboro, NJ (US);
Kevin R. Campos, Berkeley Heights, NJ (US);
Artis Klapars, Scotch Plains, NJ (US);
J. Christopher McWilliams, Hoboken, NJ (US);
C. Scott Shultz, Maplewood, NJ (US);
Debra J. Wallace, Scotch Plains, NJ (US);
Alex M. Chen, Metuchen, NJ (US);
Lisa F. Frey, Somerset, NJ (US);
Andrey V. Peresypkin, Cranford, NJ (US);
Yaling Wang, Westfield, NJ (US);
Robert M. Wenslow, Cream Ridge, NJ (US);
Cheng-Yi Chen, Plainsboro, NJ (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
The present invention is directed to a practical process for the preparation of an enamide (II) by palladium catalyzed coupling of a primary amide (IV) with a compound of structural formula (III), as shown below: As well as to crystalline forms of a compound produced by this process, in particular, an anhydrous crystal form, Form B, and crystalline solvates falling into three patterns, Type 1, Type 2, and Type 3, and crystalline intermediate compounds produced in the process. Still further, the present invention relates to the stereoselective reduction of the tetrasubstituted enamide (II) to the corresponding amide (I).