The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2009
Filed:
Mar. 04, 2005
Ashok Kumar, Maharashtra, IN;
Ketan Dhansukhlal Vyas, Maharashtra, IN;
Sanjay Govind Barve, Maharashtra, IN;
Priti Jayesh Bhayani, Maharashtra, IN;
Sanjay Nandavadekar, Maharashtra, IN;
Chirag Hasmukh Shah, Maharashtra, IN;
Sandeep Madhavrao Burudkar, Maharashtra, IN;
Lavkesh Dayashankar Kushwaha, Maharashtra, IN;
Ashok Kumar, Maharashtra, IN;
Ketan Dhansukhlal Vyas, Maharashtra, IN;
Sanjay Govind Barve, Maharashtra, IN;
Priti Jayesh Bhayani, Maharashtra, IN;
Sanjay Nandavadekar, Maharashtra, IN;
Chirag Hasmukh Shah, Maharashtra, IN;
Sandeep Madhavrao Burudkar, Maharashtra, IN;
Lavkesh Dayashankar Kushwaha, Maharashtra, IN;
IPCA Laboratories Ltd., Mumbai, IN;
Abstract
An improved process for the manufacture of Clopidogrel starting from 2-(2-thienyl) ethylamine, which eliminates the isolation of an unstable intermediate like 2-(2-thienyl) ethyl formimine by subjecting it to a one pot cyclization to get 4, 5, 6, 7-tetrahydrothieno (3,2-c) pyridine of Formula II and further reacting with halo-compound of Formula III (where X is Cl or Br) at 20 to 90° C. temperature characterized in a solvent like water and/or dichloroethane in presence of organic or inorganic bases is disclosed herein. This invention further discloses a process for resolution of racemic Clopidogrel into its optical antipodes and converting the dextroclopidogrel base into its known polymorphs namely 'Form I' or 'Form II' in solvents selected from methyl propyl ketone, methyl isopropyl ketone, diethyl ketone or their mixture thereof, mixture of ethyl acetate and methyl propyl ketone, mixture of ethyl acetate and methyl isopropyl ketone, or mixture of ethyl acetate and diethyl ketone or ethyl acetate.