The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2009
Filed:
Jun. 11, 2003
Lynne Canne Bannen, Pacifica, CA (US);
Erick W. CO, Redwood City, CA (US);
Vasu Jammalamadaka, Pleasanton, CA (US);
John M. Nuss, Danville, CA (US);
Moon Hwan Kim, Palo Alto, CA (US);
Donna Tra Le, San Jose, CA (US);
Amy Lew, Milpitas, CA (US);
Shumeye Mamo, Berkeley, CA (US);
Zhaoyang Wen, San Francisco, CA (US);
Wei Xu, Danville, CA (US);
Lynne Canne Bannen, Pacifica, CA (US);
Erick W. Co, Redwood City, CA (US);
Vasu Jammalamadaka, Pleasanton, CA (US);
John M. Nuss, Danville, CA (US);
Moon Hwan Kim, Palo Alto, CA (US);
Donna Tra Le, San Jose, CA (US);
Amy Lew, Milpitas, CA (US);
Shumeye Mamo, Berkeley, CA (US);
Zhaoyang Wen, San Francisco, CA (US);
Wei Xu, Danville, CA (US);
Symphony Evolution, Inc., Rockville, MD (US);
Abstract
The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.