The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 2009
Filed:
Oct. 29, 2004
William Alexander Denny, Auckland, NZ;
Graham John Atwell, Auckland, NZ;
Shangjin Yang, Auckland, NZ;
William Robert Wilson, Waiuku, NZ;
Adam Vorn Patterson, Auckland, NZ;
Nuala Ann Helsby, Auckland, NZ;
William Alexander Denny, Auckland, NZ;
Graham John Atwell, Auckland, NZ;
Shangjin Yang, Auckland, NZ;
William Robert Wilson, Waiuku, NZ;
Adam Vorn Patterson, Auckland, NZ;
Nuala Ann Helsby, Auckland, NZ;
Auckland Uniservices Limited, Auckland, NZ;
Abstract
The present invention relates to a novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumors, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy (GPEPT) and antibody-directed enzymeprodrug therapy (ADEPT), in conjunction with nitroreductase enzymes.