The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 08, 2009

Filed:

Oct. 18, 2006
Applicants:

Lowell J. Brady, Tacoma, WA (US);

Kevin M. Klucher, Bellevue, WA (US);

Chung Chan, Issaquah, WA (US);

Dennis L. Dong, Bellevue, WA (US);

Hong Y. Liu, Seattle, WA (US);

Paul O. Sheppard, Granite Falls, WA (US);

Thomas R. Bukowski, Seattle, WA (US);

Inventors:

Lowell J. Brady, Tacoma, WA (US);

Kevin M. Klucher, Bellevue, WA (US);

Chung Chan, Issaquah, WA (US);

Dennis L. Dong, Bellevue, WA (US);

Hong Y. Liu, Seattle, WA (US);

Paul O. Sheppard, Granite Falls, WA (US);

Thomas R. Bukowski, Seattle, WA (US);

Assignee:

ZymoGenetics, LLC, Nashville, TN (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 21/02 (2006.01); C12N 15/09 (2006.01); C12N 15/64 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
Abstract

Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.


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