The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2009
Filed:
Nov. 14, 2003
Wei Xu, Danville, CA (US);
Erick Wang CO, Redwood City, CA (US);
John M. Nuss, Danville, CA (US);
Moon Hwan Kim, Palo Alto, CA (US);
Rhett Ronald Klein, San Francisco, CA (US);
Donna Tra Le, San Jose, CA (US);
Amy Lew Tsuhako, Milpitas, CA (US);
Jason Jevious Parks, Sacramento, CA (US);
Zhaoyang Wen, San Francisco, CA (US);
Wei Cheng, San Jose, CA (US);
Wei Xu, Danville, CA (US);
Erick Wang Co, Redwood City, CA (US);
John M. Nuss, Danville, CA (US);
Moon Hwan Kim, Palo Alto, CA (US);
Rhett Ronald Klein, San Francisco, CA (US);
Donna Tra Le, San Jose, CA (US);
Amy Lew Tsuhako, Milpitas, CA (US);
Jason Jevious Parks, Sacramento, CA (US);
Zhaoyang Wen, San Francisco, CA (US);
Wei Cheng, San Jose, CA (US);
Symphony Evolution, Inc., Rockville, MD (US);
Abstract
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk-1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.