The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 01, 2009
Filed:
Apr. 27, 2005
Muthiah Manoharan, Weston, MA (US);
Kallanthottathil G. Rajeev, Cambridge, MA (US);
Venkitasamy Kesavan, Woburn, MA (US);
Muthiah Manoharan, Weston, MA (US);
Kallanthottathil G. Rajeev, Cambridge, MA (US);
Venkitasamy Kesavan, Woburn, MA (US);
Alnylam Pharmaceuticals, Cambridge, MA (US);
Abstract
The present invention provides single-stranded and double-stranded oligonucleotides comprising at least one aralkyl ligand that improves the pharmacokinetic properties of the oligonucleotides. The aralkyl ligands of the present invention include naproxen, ibuprofen and derivatives thereof. The present invention also provides methods for modulating gene expression using the modified oligonucleotide compounds and compositions comprising those modified oligonucleotides.