The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2009
Filed:
Dec. 06, 2006
Chunhao Zhang, LaSalle, CA;
Clifford William Coughlin, Plattsburgh, NY (US);
Anthony Pilcher, Colchester, VT (US);
Adam P. Michaud, Lawrenceville, NJ (US);
James S. Farina, Warwick, NY (US);
Ayman Sahli, Amman, JO;
Chunhao Zhang, LaSalle, CA;
Clifford William Coughlin, Plattsburgh, NY (US);
Anthony Pilcher, Colchester, VT (US);
Adam P. Michaud, Lawrenceville, NJ (US);
James S. Farina, Warwick, NY (US);
Ayman Sahli, Amman, JO;
Wyeth, Madison, NJ (US);
Abstract
A scalable process for the preparation of a rapamycin 42-ester by reacting a rapamycin 42-ester boronate with a diol and purifying crude rapamycin 42-ester by recrystallization and treatment with a diol is provided. Also provided is a method for isolating and purifying a rapamycin 42-ester boronate from mother liquors comprising acetone and rapamycin contaminants.