The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 24, 2009

Filed:

Apr. 17, 2002
Applicants:

Radmila Mileusnic, Milton Keynes, GB;

Steven Peter Russell Rose, Milton Keynes, GB;

Inventors:

Radmila Mileusnic, Milton Keynes, GB;

Steven Peter Russell Rose, Milton Keynes, GB;

Assignee:

The Open University, Milton Keynes, GB;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/06 (2006.01); A61K 38/07 (2006.01); A61K 38/08 (2006.01); A61K 47/48 (2006.01); C07K 2/00 (2006.01); C07K 7/04 (2006.01); C07K 5/08 (2006.01); C07K 1/00 (2006.01); C07K 1/107 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention provides a compound having formula X-Arg-Xaa-Arg-Xin which Xand Xare up to 30 amino acid residues and Xaa is an amino acid residue. A preferred compound is the tripeptide Arg-Glu-Arg which corresponds to amino acid residues 328 to 330 of human amyloid precursor protein. The invention further provides a derivative of a polypeptide having the formula: X-Arg-Xaa-Arg-Xwherein Xand X, which may be the same or different, each represents from zero to 30 natural or synthetic amino acid residues or derivatives thereof and Xaa represents a natural or synthetic amino acid residue or derivative thereof, at least one functional group of at least one said amino acid residue or derivative thereof being protected by a protective group. The compounds of the invention are believed to be useful in the treatment of Alzheimer's disease and as cognitive enhancers.


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