The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 24, 2009
Filed:
Nov. 04, 2005
Joffre B. Baker, Montara, CA (US);
John L. Bryant, Allison Park, PA (US);
Soonmyung Paik, Pittsburgh, PA (US);
Steven Shak, Hillsborough, CA (US);
Joffre B. Baker, Montara, CA (US);
John L. Bryant, Allison Park, PA (US);
Soonmyung Paik, Pittsburgh, PA (US);
Steven Shak, Hillsborough, CA (US);
Genomic Health, Inc., Redwood City, CA (US);
NSABP Foundation, Inc., Pittsburgh, PA (US);
Abstract
The present invention relates to quantitative molecular indicators that can guide clinical decisions in breast cancer, such as estrogen receptor (ESR1)-positive, lymph node-negative breast cancer. In particular, the invention concerns certain genes, the varied expression of which indicates the likelihood of recurrence of surgically resected breast cancer in patients who are not treated with a therapeutic agent in the adjuvant setting. In addition, the invention concerns the use of quantitative measurement of the expression of certain genes, including the ESR1 gene, that measure as a continuous variable, to determine (a) the likelihood of a beneficial response to the anti-estrogen therapeutic agent, such as tamoxifen; and (b) the potential magnitude of beneficial response to chemotherapy.