The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 24, 2009

Filed:

Dec. 13, 2005
Applicants:

Richard P. Darveau, Redmond, WA (US);

Robert Reife, Redmond, WA (US);

Keith Knutson, Rochester, MN (US);

Inventors:

Richard P. Darveau, Redmond, WA (US);

Robert Reife, Redmond, WA (US);

Keith Knutson, Rochester, MN (US);

Assignee:

University of Washington, Seattle, WA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/00 (2006.01); A61K 47/00 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

A preparation containing lipopolysaccharide (LPS) ofhaving a molecular negative mass ion of 1435 or 1449 is used as an immune system modulator to redirect a host's immune system against an antigen of interest. The 1435/1449 LPS preparation can be isolated fromor prepared as a derivative or mimetic thereof. The immunomodulating preparations of1435/1449 can be used as a vaccine adjuvant, and can be used to stimulate an immune response against a selected antigen associated with a disease of interest, such an antigen associated with a tumor, infectious disease, autoimmune disease, MHC antigen, or to modulate asthma or other inflammatory conditions.


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