The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 17, 2009
Filed:
Dec. 05, 2006
Peter Christopher Ray, Newhouse, GB;
Peter Christopher Ray, Newhouse, GB;
N.V. Organon, Oss, NL;
Abstract
The invention relates to isoquinoline derivatives having the general Formula I wherein X is O, S or NH; Y is OH or NH; m is 0, 1 or 2; n is 1 or 2; Ris H, when Y is NH; or Ris H, (C)alkyl or halogen, when Y is OH; Rand Rare independently H, (C)alkyl or halogen; R is H or (C)alkyl, optionally substituted with OH, (C)-alkyloxy, (C)alkyloxycarbonyl, (C)cycloalkyl, which may optionally comprise a heteroatom selected from O and S, (C)aryl, (C)aryloxy or a 5- or 6-membered heteroaryl group comprising 1-3 heteroatoms independently selected from O, N and S, each aryl or heteroaryl group being optionally substituted with 1-3 substituents independently selected from (C)alkyl, (C)alkyloxy, (C)alkylsulfonyl and halogen; or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same as well as to the use of the isoquinoline derivatives in the treatment of ROCK-I related disorders such as hypertension, atherosclerosis and glaucoma.