The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2009
Filed:
Nov. 13, 2003
Maria Petrou, Guildford, GB;
Anastasios Kesidis, Athens, GR;
Margaret Jai Varga, Malvern, GB;
Paul Gerard Ducksbury, Malvern, GB;
Maria Petrou, Guildford, GB;
Anastasios Kesidis, Athens, GR;
Margaret Jai Varga, Malvern, GB;
Paul Gerard Ducksbury, Malvern, GB;
Qinetiq Limited, , GB;
Abstract
A method of histological assessment of nuclear pleomorphism to identify potential cell nuclei divides image data into overlapping sub-images. It uses principal component analysis to derive monochromatic image data, followed by Otsu thresholding to produce a binary image. It removes image regions at sub-image boundaries, unsuitably small image regions and holes in relatively large image regions. It then reassembles the resulting sub-images into a single image. Perimeters (P) and areas (A) of image regions which are potential cell nuclei are determined and used in calculating nuclear shape factors P/A. Nuclear pleomorphism is assessed as relatively low, moderate or high according to whether predetermined shape factor thresholds indicate a mean cell nucleus shape factor for an image is relatively low, moderate or high.