The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2009
Filed:
Sep. 15, 2003
Magnus Hook, Houston, TX (US);
Yi Xu, Houston, TX (US);
Jouko V. Sillanpaa, Houston, TX (US);
Narayana Sthanam, Birmingham, AL (US);
Karthe Ponnuraj, Birmingham, AL (US);
Joseph M. Patti, Cumming, GA (US);
Jeff T. Hutchins, Cumming, GA (US);
Andrea Hall, Acworth, GA (US);
Maria G. Bowden, Sugarland, TX (US);
Magnus Hook, Houston, TX (US);
Yi Xu, Houston, TX (US);
Jouko V. Sillanpaa, Houston, TX (US);
Narayana Sthanam, Birmingham, AL (US);
Karthe Ponnuraj, Birmingham, AL (US);
Joseph M. Patti, Cumming, GA (US);
Jeff T. Hutchins, Cumming, GA (US);
Andrea Hall, Acworth, GA (US);
Maria G. Bowden, Sugarland, TX (US);
The Texas A&M University System, College Station, TX (US);
Inhibitex, Inc., Alpharetta, GA (US);
The UAB Research Foundation, Birmingham, AL (US);
Abstract
A bioinformatic method is provided for identifying and isolating proteins with MSCRAMM®—like characteristics from Gram positive bacteria, such asandbacteria, which can then be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be used to generate antibodies useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.