The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2009
Filed:
Mar. 17, 2008
Francis J. Carr, Balmedie, GB;
Graham Carter, By Newmachar, GB;
Tim Jones, Babraham, GB;
John Watkins, Girton, GB;
Matthew Baker, Littleport, GB;
Francis J. Carr, Balmedie, GB;
Graham Carter, By Newmachar, GB;
Tim Jones, Babraham, GB;
John Watkins, Girton, GB;
Matthew Baker, Littleport, GB;
Merck Patent GmbH, Darmstadt, DE;
Abstract
The present invention relates a modified human interferon beta (INFβ) which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered in vivo to a human. The modified human INFβ comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by an amino acid residue substitution selected from the group consisting of L57A, L57C, L57D L57E, L57G, L57H, L57K, L57N, L57P, L57Q, L57R, L57S, and L57T and an additional substitution selected from the group consisting of the H140A, H140C, H140G, and H140P.