The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2009
Filed:
Jan. 26, 2004
Applicants:
Sudha Shenoy, Durham, NC (US);
Robert J. Lefkowitz, Durham, NC (US);
Inventors:
Sudha Shenoy, Durham, NC (US);
Robert J. Lefkowitz, Durham, NC (US);
Assignee:
Duke University, Durham, NC (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 19/00 (2006.01); C07K 14/47 (2006.01); C12N 15/11 (2006.01); G01N 33/566 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to a modified arrestin which includes an arrestin molecule and a ubiquitin molecule. This modified arrestin has an increased affinity for a GPCR, and traffics with the GPCR into endosomes. The present invention further relates to a method of screening compounds and sample solutions for a GPCR agonist, antagonist, inverse agonist, or desensitization active compound. The modified arrestin is useful in the methods of the present invention.