The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 10, 2009
Filed:
Feb. 09, 2004
Kirvin L. Hodge, Laurel, MD (US);
Shalini Sharma, Gaithersburg, MD (US);
Albert C. Lee, St. Louis, MO (US);
Reid W. Von Borstel, Potomac, MD (US);
Kirvin L. Hodge, Laurel, MD (US);
Shalini Sharma, Gaithersburg, MD (US);
Albert C. Lee, St. Louis, MO (US);
Reid W. von Borstel, Potomac, MD (US);
Wellstat Therapeutics Corporation, Gaithersburg, MD (US);
Abstract
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, artherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 0, 1, 2, 4 or 5; q is 0 or 1; t is 0 or 1; Ris alkyl from 1 to 3 carbon atoms; Ris hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by or 1 or 2 groups selected from: halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloaldyl having from 3 to 6 ring carbon atoms wherein the cycloaldyl is unsubstitited or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compounds of formula (I) by a ring carbon; and Ris hydrogen or alkyl having 1 or 2 carbon atoms. Alternatively, when Ris hydrogen, the biologically active agent can be a pharmaceutically acceptable salt of the compound of Formula (I).