The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2009
Filed:
Jun. 14, 2007
Thomas Ammann, Muttenz, CH;
Stephan Goetzoe, Muttenz, CH;
Bernd Thern, Basel, CH;
Sandra Welz, Neuenburg, DE;
Klaus-juergen Wolter, Muellheim, DE;
Thomas Ammann, Muttenz, CH;
Stephan Goetzoe, Muttenz, CH;
Bernd Thern, Basel, CH;
Sandra Welz, Neuenburg, DE;
Klaus-Juergen Wolter, Muellheim, DE;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
Disclosed is a process for the manufacture of pseudo proline dipeptides of the formula wherein Ris a side chain of an alpha amino acid, Ris an amino protecting group and Rand Rare independently either hydrogen or C-alkyl, and Ris hydrogen or methyl starting from an amino acid derivative of the formula wherein Rand Rare as defined above. Pseudo proline dipeptides can be used as reversible protecting groups for Ser, Thr and Cys and thus are versatile tools in peptide chemistry.