The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2009
Filed:
Feb. 16, 2006
Olga Etlin, Beer-Sheva, IL;
Mohammed Alnabari, Hura, IL;
Yana Sery, Beer-Sheva, IL;
Edna Danon, Meitar, IL;
Oded Arad, Rechovot, IL;
Joseph Kaspi, Givatayim, IL;
Olga Etlin, Beer-Sheva, IL;
Mohammed Alnabari, Hura, IL;
Yana Sery, Beer-Sheva, IL;
Edna Danon, Meitar, IL;
Oded Arad, Rechovot, IL;
Joseph Kaspi, Givatayim, IL;
Chemagis, Ltd., Bnei Brak, IL;
Abstract
The present invention provides a process for preparing highly pure Temozolomide base which includes recovery from the purification mother liquors by using an anionic exchange resin. By treating Temozolomide hydrochloride with a mixture of an organic acid, a water miscible organic solvent, and water, Temozolomide free base is obtained in an acidic medium. Due to the high sensitivity of Temozolomide to basic pH values the recovery-including process is especially advantageous because it enables obtaining high yields of highly pure Temozolomide base in acidic conditions. The process for producing Temozolomide base includes hydrolysis of the starting material 8-cyano-3-methyl-[3H]-imidazo[5,1-d]-tetrazin-4-one in acidic medium to obtain highly pure Temozolomide hydrochloride in high yield.