Pyrazole compounds

Abstract

Compounds of formula (IA) or (IB) or a salt, N-oxide, hydrate or solvate thereof are inhibitors of HSP90, and are of value in the treatment of diseases responsive to HSP90 inhibition such as cancers. In the formulae, Ar is an aryl, aryl(C-Calkyl), aryl(C-Calkyl), heteroaryl, heteroarylaryl(C-Calkyl), or heteroarylaryl(C-Calkyl) group, any of which being optionally substituted in the aryl or heteroaryl part thereof; R, is hydrogen or optionally substituted C-Calkyl; Ris hydrogen, optionally substituted cycloalkyl, cycloalkenyl, C-Calkyl, C-Calkenyl, or C-Calkynyl; or a carboxyl, carboxamide or carboxyl ester group; and ring A is a non aromatic carbocyclic or heterocyclic ring wherein (i) a ring carbon is optionally substituted, and/or (ii) a ring nitrogen is optionally substituted by a group of formula -(Alk)(Cyc)-(Alk)-(Z)r (Alk)Q where Alk, Alkand Alkare optionally substituted C-Calkyl, Cyc is an optionally substituted carbocyclic or heterocyclic radical; m, n, p, r and s are independently 0 or 1, Z is -0-, —S—, —(C═O)—, —S02-, —C(═O)O—, —OC(═O)—, —NW—, —C(═O)NRA-, —NRC(═O)—, —SONR—, or —NRSO— wherein Ris hydrogen or C-Calkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical.