The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2009
Filed:
Jan. 13, 2006
Juha Punnonen, Belmont, CA (US);
Alexandra L. L. Lazetic, San Jose, CA (US);
Steven R. Leong, Berkeley, CA (US);
Jean Chia-chun Chang, Los Gatos, CA (US);
Juha Punnonen, Belmont, CA (US);
Alexandra L. L. Lazetic, San Jose, CA (US);
Steven R. Leong, Berkeley, CA (US);
Jean Chia-Chun Chang, Los Gatos, CA (US);
Maxygen, Inc., Redwood City, CA (US);
Abstract
The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.