The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2009
Filed:
Apr. 28, 2003
Takeshi Yura, Aichi-ken, JP;
Muneto Mogi, Nara-ken, JP;
Klaus Urbahns, Lund, SE;
Hiroshi Fujishima, Nara-ken, JP;
Tsutomu Masuda, Aichi-ken, JP;
Toshiya Moriwaki, Nara-ken, JP;
Nagahiro Yoshida, Kyoto-fu, JP;
Toshio Kokubo, Nara-ken, JP;
Masahiro Shiroo, Teversham, GB;
Masaomi Tajimi, Aichi-ken, JP;
Yasuhiro Tsukimi, Hyogo-ken, JP;
Noriyuki Yamamoto, Osaka-fu, JP;
Takeshi Yura, Aichi-ken, JP;
Muneto Mogi, Nara-ken, JP;
Klaus Urbahns, Lund, SE;
Hiroshi Fujishima, Nara-ken, JP;
Tsutomu Masuda, Aichi-ken, JP;
Toshiya Moriwaki, Nara-ken, JP;
Nagahiro Yoshida, Kyoto-fu, JP;
Toshio Kokubo, Nara-ken, JP;
Masahiro Shiroo, Teversham, GB;
Masaomi Tajimi, Aichi-ken, JP;
Yasuhiro Tsukimi, Hyogo-ken, JP;
Noriyuki Yamamoto, Osaka-fu, JP;
Xention Limited, Cambridgeshire, GB;
Abstract
This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence, inflammatory disorders such as asthma and COPD.