The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 03, 2009
Filed:
Nov. 18, 2005
Yi Zheng, Cincinnati, OH (US);
Huzoor Akbar, Athens, OH (US);
David A. Williams, Cincinnati, OH (US);
Wieslaw Adam Mazur, Mason, OH (US);
Yi Zheng, Cincinnati, OH (US);
Huzoor Akbar, Athens, OH (US);
David A. Williams, Cincinnati, OH (US);
Wieslaw Adam Mazur, Mason, OH (US);
Cincinnati Children's Hospital Medical Center, Cincinnati, OH (US);
Abstract
The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.