The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2009
Filed:
Oct. 28, 2003
Ilia Davydov, North Potomac, MD (US);
John H. Kenten, Boyds, MD (US);
Hans Biebuyck, Rockville, MD (US);
Pankaj Oberoi, Rockville, MD (US);
Ilia Davydov, North Potomac, MD (US);
John H. Kenten, Boyds, MD (US);
Hans Biebuyck, Rockville, MD (US);
Pankaj Oberoi, Rockville, MD (US);
Meso Scale Technologies LLC, Gaithersburg, MD (US);
Abstract
The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel substrates, enzymes and modulators of N-end rule ubiquitylation. The present invention also relates to specific substrates of N-end rule ubiquitylation as well as activated fragments of these substrates, proteases that expose N-degrons in these substrates, ubiquitin ligases that ubiquitylate these substrates and inhibitors of the ubiquitylation of these substrates.