The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2009
Filed:
Apr. 27, 2005
Edward A. Kesicki, Bothell, WA (US);
John Joseph Gaudino, Longmont, CO (US);
Adam Wade Cook, Longmont, CO (US);
Scott Douglas Cowen, Longmont, CO (US);
Laurence Edward Burgess, Boulder, CO (US);
Edward A. Kesicki, Bothell, WA (US);
John Joseph Gaudino, Longmont, CO (US);
Adam Wade Cook, Longmont, CO (US);
Scott Douglas Cowen, Longmont, CO (US);
Laurence Edward Burgess, Boulder, CO (US);
Icos Corporation, Bothell, WA (US);
Abstract
Compounds of the formula wherein: Y' is O or S, W′ is optionally substituted,Z′ is selected from the group consisting of wherein Q′ is ORand Ris CalkyleneCheterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.