The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2009
Filed:
Feb. 03, 2004
Antonino Cattaneo, Trieste, IT;
Amos Maritan, Trieste, IT;
Michela Visintin, Trieste, IT;
Terrence Rabbitts, Cambridge, GB;
Giovanni Settanni, Orbassano, IT;
Antonino Cattaneo, Trieste, IT;
Amos Maritan, Trieste, IT;
Michela Visintin, Trieste, IT;
Terrence Rabbitts, Cambridge, GB;
Giovanni Settanni, Orbassano, IT;
Abstract
A method of identifying at least one consensus sequence for an intracellular antibody (ICS) comprising the steps of: creating a database comprising sequences of validated intracellular antibodies (VIDA database) and aligning the sequences of validated intracellular antibodies according to Kabat; determining the frequency with which a particular amino acid occurs in each of the positions of the aligned antibodies; selecting a frequency threshold value (LP or consensus threshold) in the range from 70% to 100%; identifying the positions of the alignment at which the frequency of a particular amino acid is greater than or equal to the LP value; and identifying the most frequent amino acid, in the position of said alignment.