The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2009
Filed:
Oct. 07, 2008
Steven Mark Dunn, Abingdon, GB;
Yi LI, Abingdon, GB;
Jonathan Michael Boulter, Abingdon, GB;
Lucy Boulter, Legal Representative, Abingdon, GB;
Steven Mark Dunn, Abingdon, GB;
Yi Li, Abingdon, GB;
Jonathan Michael Boulter, Abingdon, GB;
Lucy Boulter, legal representative, Abingdon, GB;
Immunocore Limited, Oxford, GB;
Abstract
A method of increasing the affinity and/or decreasing the off-rate of a given TCR specific for a given target pMHC, comprising creating a plurality of TCRs having an α chain CDR2 sequence and/or a β chain CDR2 sequence different from the corresponding CDR2 sequence(s) of the given TCR but having the same α and β CDR1 and CDR3 sequences as the given TCR, determining the affinity and/or off-rate of members of said plurality of TCRs for the target pMHC, and selecting one or more members having at least a 10-fold greater affinity for the target pMHC than the given TCR and/or a 10-fold slower off-rate for the target pMHC than the given TCR.