The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2009
Filed:
Jan. 05, 2004
Mark A. Schenerman, Reisterstown, MD (US);
Jose Casas-finet, Gaithersburg, MD (US);
Jinhua Feng, North Potomac, MD (US);
Guillermo Tous, East Windsor, NJ (US);
Mark A. Schenerman, Reisterstown, MD (US);
Jose Casas-Finet, Gaithersburg, MD (US);
Jinhua Feng, North Potomac, MD (US);
Guillermo Tous, East Windsor, NJ (US);
MedImmune, LLC, Gaithersburg, MD (US);
Abstract
The present invention provides stabilized immunoglobulin molecules that have increased storage stability and/or in vivo half-lives due to the mutation of one or more amino acids that would otherwise render the immunoglobulin molecules susceptible to degradation. In a preferred embodiment, the stabilized immunoglobulins of the invention have mutations at the heavy chain constant domain hinge region. Such stabilized immunoglobulin molecules, i.e., immunoglobulin molecules with increased storage stability have one or more of the following advantages they are more readily transported and/storable for longer periods and/or less stringent conditions than non-stabilized counterparts; that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such stabilized molecules.