The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2009
Filed:
Aug. 04, 2003
Dasheng Wang, Dublin, OH (US);
Rex T. Gallagher, Hampton, NH (US);
John S. Juchum, Gloucester, MA (US);
James H. Johnson, Merrimac, MA (US);
Dasheng Wang, Dublin, OH (US);
Rex T. Gallagher, Hampton, NH (US);
John S. Juchum, Gloucester, MA (US);
James H. Johnson, Merrimac, MA (US);
Natural Pharmaceuticals, Inc., Beverly, MA (US);
Abstract
The invention relates to methods and compositions for converting taxane amides to paclitaxel or other taxanes. In one alternative embodiment, the present invention comprises; (i) selectively protecting at least one OH group of a taxane amide; (ii) contacting the taxane amide with a transition metal compound to reduce the amide; (iii) contacting the reduced amide with an agent capable of substantially removing the transition metal; (iv) contacting the reduced amide with a hydrolyzing amount of acid to form a taxane amine salt in solution; (v) adding a sufficient amount of solvent to solidify the amine salt; and (vi) converting the taxane amine salt into paclitaxel or other taxanes.