The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2009
Filed:
Mar. 05, 2007
Processes for preparing water-soluble polyethylene glycol conjugates of macrolide immunosuppressants
Applicants:
Jianxin Gu, River Edge, NJ (US);
Mark Ruppen, Garnerville, NY (US);
Tianmin Zhu, Monroe, NY (US);
Mahdi Fawzi, Morristown, NJ (US);
Inventors:
Jianxin Gu, River Edge, NJ (US);
Mark Ruppen, Garnerville, NY (US);
Tianmin Zhu, Monroe, NY (US);
Mahdi Fawzi, Morristown, NJ (US);
Assignee:
Wyeth, Madison, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/18 (2006.01);
U.S. Cl.
CPC ...
Abstract
Processes are described for preparing 42-pegylated rapamycins including reacting a rapamycin with an acylating agent in the presence of a lipase to form an acylated rapamycin and reacting the acylated rapamycin with a methoxy poly(ethylene glycol) derivative in the presence of a base. Also described are processes for preparing 32-pegylated tacrolimus and/or ascomycin using these steps.