The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2009
Filed:
Jun. 25, 2004
Theodore A. Yednock, Forest Knolls, CA (US);
Stephen B. Freedman, San Francisco, CA (US);
Ivan Lieberburg, Berkeley, CA (US);
Michael A. Pleiss, Sunnyvale, CA (US);
Andrei W. Konradi, San Francisco, CA (US);
George Shopp, South San Francisco, CA (US);
Elizabeth Messersmith, El Cerrito, CA (US);
Theodore A. Yednock, Forest Knolls, CA (US);
Stephen B. Freedman, San Francisco, CA (US);
Ivan Lieberburg, Berkeley, CA (US);
Michael A. Pleiss, Sunnyvale, CA (US);
Andrei W. Konradi, San Francisco, CA (US);
George Shopp, South San Francisco, CA (US);
Elizabeth Messersmith, El Cerrito, CA (US);
Elan Pharmaceuticals Inc., South San Francisco, CA (US);
Abstract
This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha-4 integrin or an immunologically active antigen binding fragment in therapeutically effective amounts. The application also relates generally to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and small molecule alpha-4 integrin antagonist that inhibits the alpha-4 integrin (α4 integrin) interaction with VCAM-1. The invention further relates to methods of preparing the compounds and methods of using the compounds and compositions.