Acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same

Abstract

The present invention relates to an acyclic nucleoside phosphonate derivative represented by the following formula (1): in whichrepresents single bond or double bond, R, R, R, Rand Rare defined herein, Y represents —O—, —S—, —CH(Z)-, ═C(Z)-, —N(Z)-, ═N—, or —SiH(Z)-, wherein Z represents hydrogen, hydroxy or halogen, or represents C-C-alkyl, C-C-alkoxy, allyl, hydroxy-C-C-alkyl, C-C-aminoalkyl or phenyl, Q represents a group having the following formula: wherein X, and Xindependently of one another represent hydrogen, amino, hydroxy or halogen, or represent C-C-alkyl, C-C-alkoxy, allyl, hydroxy-C-C-alkyl, phenyl or phenoxy each of which is optionally substituted by nitro or C-C-alkoxy, or represent C-C-arylthio which is optionally substituted by nitro, amino, C-C-alkyl or C-C-alkoxy, or represent C-C-arylamino, C-C-alkylamino, di(C-C-alkyl)amino, C-C-cycloalkylamino or a structure of wherein n denotes an integer of 1 or 2 and Yrepresents O, CHor N—R (R represents C-C-alkyl or C-C-aryl), which is useful as an antiviral agent (particularly, against hepatitis B virus), pharmaceutically acceptable salts, stereoisomers, and a process for the preparation thereof.