The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2009
Filed:
Oct. 23, 2006
Barbara Upmeier, Iffeldorf, DE;
Ralf Bollhagen, Penzberg, DE;
Alfred Engel, Tutzing, DE;
Elke Faatz, Huglfing, DE;
Peter Schaarschmidt, Uffing, DE;
Christian Scholz, Penzberg, DE;
Toralf Zarnt, Iffeldorf, DE;
Barbara Upmeier, Iffeldorf, DE;
Ralf Bollhagen, Penzberg, DE;
Alfred Engel, Tutzing, DE;
Elke Faatz, Huglfing, DE;
Peter Schaarschmidt, Uffing, DE;
Christian Scholz, Penzberg, DE;
Toralf Zarnt, Iffeldorf, DE;
Roche Diagnostics Operations, Inc., Indianapolis, IN (US);
Abstract
A soluble rubella E1 antigen variant is disclosed that comprises amino acids 334-409 of the native rubella E1 peptide, but lacks the C-terminal end and at least the transmembrane region and the anchor segment as well as at least the amino acids 143 to 164. Also described is a recombinant DNA molecule encoding the rubella E1 antigen variants which are recombinantly expressed as a chaperone fusion protein, refolded into a soluble and immunoreactive conformation, and further used for the serological detection of anti-rubella antibodies. In addition, also disclosed is a method for the detection, determination and quantification of anti-rubella antibodies of IgG and/or IgM subclass in a sample wherein the rubella E1 antigen is used as a capture reagent and/or binding partner for the antibodies.