Multifunctional reagent for the synthesis of thiol modified oligomers

Abstract

The invention relates to compounds of formula (I), wherein Z represents a hydrocarbon with 2 to 28 C atoms, wherein Z can also comprise elements N, O, P, S, Si and halogen as heteroatoms, Rand Rare identical or different sulfur protecting groups, wherein both S atoms can also form a disulfide bridge and in said case Rand Rare not present; protecting group Yrepresents protecting group NH, protecting group NR, protecting group O, CONH protecting group, protecting group OOC, protecting group S—S, —CH(protecting group O)or —CR(protecting group O)or protecting group S; Yrepresents —OH, —NH, —NHR, —NRR, —COOH, —COCI, —COOCO—R, —CONH, —CONHR, —COOR, —SOH, —SOI, —SH, —S—SR, —CHO, —COR, —CHO, halogen, —N, —NH—NH, —NCO, —NCS, wherein Rrepresents alkyl, heteroalkyl, aryl, cycloalkyl or a protecting group, wherein Rcan be identical or different in groups Yand Y, Ris s protecting group, wherein Rcan be identical or different in groups Yand Y, and wherein Rand Rcan be identical or different, Rrepresents alkyl, aryl or cycloalkyl, wherein Rcan be identical or different in groups Yand Yand Rrepresents alkyl, heteroalkyl, aryl or cycloalkyl, wherein Rcan be identical or different in groups Yand Y, wherein Ycan also represent a group of formula (II) or formula (III), wherein Xrepresents halogen or a substituted amine, Xrepresents an alkyl, alkoxy, aryloxy radical or a cyano derivative of an alkyl, alkoxy, aryloxy radical, Xrepresents halogen, an amino function or oxygen and Xrepresents an alkyl, alkoxy, aryloxy radical or Xequals H if X=oxygen.