The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2009
Filed:
Nov. 20, 2006
Petr Benovsky, Brno, CZ;
Lambertus Thijs, Wijchen, NL;
Arjanne Overeem, Ede, NL;
Jakub Castulik, Brno, CZ;
Jie Zhu, Nijmegen, NL;
Petr Bartos, Brno, CZ;
Radomir Skoumal, Blansko, CZ;
Petr Benovsky, Brno, CZ;
Lambertus Thijs, Wijchen, NL;
Arjanne Overeem, Ede, NL;
Jakub Castulik, Brno, CZ;
Jie Zhu, Nijmegen, NL;
Petr Bartos, Brno, CZ;
Radomir Skoumal, Blansko, CZ;
Synthon BV, Nijmegen, NL;
Abstract
The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula and salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.