The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2009
Filed:
May. 24, 2007
Venkateswarlu Akella, Hyderabad, IN;
Shanavas Alikunju, Secunderabad, IN;
Ajaya Kumar Reka, Hyderabad, IN;
Ramesh Mullangi, Hyderabad, IN;
Raju Sirisilla, Hyderabad, IN;
Subrahmanyam Duvvuri, Hyderabad, IN;
Sriram Rajagopal, Chennai, IN;
Venkateswarlu Akella, Hyderabad, IN;
Shanavas Alikunju, Secunderabad, IN;
Ajaya Kumar Reka, Hyderabad, IN;
Ramesh Mullangi, Hyderabad, IN;
Raju Sirisilla, Hyderabad, IN;
Subrahmanyam Duvvuri, Hyderabad, IN;
Sriram Rajagopal, Chennai, IN;
Dr. Reddy's Laboratories Limited, Hyderabad, IN;
Dr. Reddy's Laboratories, Inc., Bridgewater, NJ (US);
Abstract
A 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2′-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.