The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2009
Filed:
Jun. 10, 2004
Lars U. Wahlberg, Asnaes, DK;
Mette Gronborg, Copenhagen NV, DK;
Philip Kusk, Lynge, DK;
Jens Tornoe, Copenhagen O, DK;
Lars U. Wahlberg, Asnaes, DK;
Mette Gronborg, Copenhagen NV, DK;
Philip Kusk, Lynge, DK;
Jens Tornoe, Copenhagen O, DK;
NsGene A/S, Ballerup, DK;
Abstract
The present invention concerns improved methods and compositions for producing a Neublastin polypeptide as well as local delivery of Neublastin to specific regions of the nervous system including the central nervous system and the eye for example by gene therapy. The invention also concerns Neublastin expression constructs which do not encode a pro-region of a Neublastin polypeptide, which expression construct result in increased secretion of bioactive Neublastin. The invention includes the delivery of Neublastin from transduced or transfected cells encapsulated into a macrocapsule with a semipermeable membrane. The invention further concerns mammalian cells capable of producing Neublastin in increased amounts.