The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2009
Filed:
Jul. 09, 2004
Reiji Kannagi, Nagoya, JP;
Mineko Izawa, Seto, JP;
Takashi Muramatsu, Nagoya, JP;
Kenji Uchimura, San Francisco, CA (US);
Hideaki Hosokawa, Suita, JP;
Reiji Kannagi, Nagoya, JP;
Mineko Izawa, Seto, JP;
Takashi Muramatsu, Nagoya, JP;
Kenji Uchimura, San Francisco, CA (US);
Hideaki Hosokawa, Suita, JP;
Japan Science & Technology Agency, Saitama, JP;
Local Government of Aichi Prefecture, Aichi-ken, JP;
Wako Pure Chemical Industries, Ltd., Osaka, JP;
Abstract
The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. The present inventors discovered that there are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore the inventors applied the discovery to diagnosis and found that colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No. 09961D, Distributor: Becton Dickinson), reacting with GlcNAc-6-sulfated sugar residues, which are produced specifically by the enzyme present in colorectal cancer and colorectal adenoma tissues could be used for the examination of colorectal cancers and colorectal adenomas.