The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2009
Filed:
Mar. 31, 2005
Peter Jan Leonard Mario Quaedflieg, Waalre, NL;
Bart Rudolf Romanie Kesteleyn, Berlare, BE;
Robert Jan Vijn, Venlo, NL;
Constantinus Simon Maria Liebregts, Helmond, NL;
Jacob Hermanus Matheus Hero Kooistra, Haren, NL;
Franciscus Alphons Marie Lommen, Horst, NL;
Peter Jan Leonard Mario Quaedflieg, Waalre, NL;
Bart Rudolf Romanie Kesteleyn, Berlare, BE;
Robert Jan Vijn, Venlo, NL;
Constantinus Simon Maria Liebregts, Helmond, NL;
Jacob Hermanus Matheus Hero Kooistra, Haren, NL;
Franciscus Alphons Marie Lommen, Horst, NL;
Tibotec Pharmaceuticals, Ltd., Little Island, Co. Cork, IE;
Abstract
The present invention relates to methods for the preparation of diastereomerically pure (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol as well as a novel intermediate, (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one for use in said methods. More in particular the invention relates to a stereoselective method for the preparation of diastereomerically pure (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol, as well as methods for the crystallization of (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one and for the epimerization of (3aR,4R,6aS) 4-methoxy-tetrahydro-furo[3,4-b]-furan-2-one to (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile