The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2009
Filed:
Mar. 16, 2006
Jeremy I. Levin, New City, NY (US);
Zhong LI, Congers, NY (US);
George Diamantidis, Randolph, NJ (US);
Frank E. Lovering, Acton, MA (US);
Weiheng Wang, Bedford, MA (US);
Jeffrey S. Condon, Cambridge, MA (US);
Yang-i Lin, Jackson, NJ (US);
Jerauld S. Skotnicki, Westfield, NJ (US);
Kaapjoo Park, Congers, NY (US);
Jeremy I. Levin, New City, NY (US);
Zhong Li, Congers, NY (US);
George Diamantidis, Randolph, NJ (US);
Frank E. Lovering, Acton, MA (US);
Weiheng Wang, Bedford, MA (US);
Jeffrey S. Condon, Cambridge, MA (US);
Yang-I Lin, Jackson, NJ (US);
Jerauld S. Skotnicki, Westfield, NJ (US);
Kaapjoo Park, Congers, NY (US);
Wyeth, Madison, NJ (US);
Abstract
This invention provides compounds of Formula I, having the structure: that are useful in treating diseases or disorders mediated by TNF-α, such as arthritis (rheumatoid arthritis (RA), juvenile RA, psoriatic arthritis, osteoarthritis etc), tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection, ankylosing spondylitis, psoriasis, sepsis, multiple sclerosis, Crohn's disease, degenerative cartilage loss, asthma, idiopathic pulmonary fibrosis, vasculitis, systemic lupus erythematosus, irritable bowel syndrome, acute coronary syndrome, hepatitis C, cachexia, COPD, stroke or type 2 diabetes, and for alleviation of symptoms thereof. The invention further provides methods for use of the compounds.