The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2009
Filed:
Oct. 25, 2004
Marie Dutreix, L'Hay les Roses, FR;
Jian-sheng Sun, Saint Maur des Fosses, FR;
Marie Dutreix, L'Hay les Roses, FR;
Jian-Sheng Sun, Saint Maur des Fosses, FR;
Institut Curie, Paris Cedex, FR;
Centre National de la Recherche Scientifique (CNRS), Paris Cedex, FR;
Museum National d'Histoire Naturelle, Paris Cedex, FR;
Institut National de la Sante et de la Recherche Medicale (INSERM), Paris Cedex, FR;
Abstract
The invention relates to double-stranded nucleic acid fragments comprising a chemically modified backbone and at least 4-1000 bp, preferably 8-500 bp, and most preferably 16-200 bp. The disclosed molecules (DRIL molecules) may interfere with DNA damage signaling and repair pathways, in particular the non homologous NHEJ pathway of double-stranded break repair. The invention discloses the application of the DRIL molecules as adjuvant compositions to be used in association with a DNA breaking treatment, particularly radiotherapy or chemotherapy, in combination with a pharmaceutically acceptable carrier, in an efficient amount to be introduced in the tumoral cell nuclei in order to trigger DNA repair induced lethality (DRIL in short) of tumoral cells/tissues.