The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2009
Filed:
Apr. 06, 2004
Sang Yup Lee, Daejeon, KR;
Zixin Deng, Shanghai, CN;
Shi Chen, Shanghai, CN;
Ki Jun Jeong, Daejeon, KR;
Xiufen Zhou, Shanghai, CN;
Sang Yup Lee, Daejeon, KR;
Zixin Deng, Shanghai, CN;
Shi Chen, Shanghai, CN;
Ki Jun Jeong, Daejeon, KR;
Xiufen Zhou, Shanghai, CN;
Korea Advanced Institute of Science and Technology, Daejeon, CN;
Abstract
The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived fromsp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and genes coding for modifier enzymes, such as ABC transporter, cytochrome P450 monooxygenase, ferredoxin, thioesterase, sugar synthetic protein, FAD-dependent monooxygenase, 4-amino-4-deoxychorismate (ADC) synthase and ADC lyase. The gene base sequence according to the present invention can be used to increase the productivity of the existing FR-008 polyketides or produce new FR-008 polyketides, through modification of its parts.