The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2009
Filed:
Jan. 23, 2004
Michael P. Cooke, Del Mar, CA (US);
Karsten Sauer, San Diego, CA (US);
Tim Wiltshire, Encinitas, CA (US);
Lisa Tarantino, Encinitas, CA (US);
Colin Fletcher, Del Mar, CA (US);
Ben Wen, Encinitas, CA (US);
Michael P. Cooke, Del Mar, CA (US);
Karsten Sauer, San Diego, CA (US);
Tim Wiltshire, Encinitas, CA (US);
Lisa Tarantino, Encinitas, CA (US);
Colin Fletcher, Del Mar, CA (US);
Ben Wen, Encinitas, CA (US);
IRM LLC, Hamilton, BM;
Abstract
This invention provides novel methods and compositions for modulating T cell differentiation and T cell responses. The modulators are identified by screening test compounds for ability to modulate an inositol 1,4,5-trisphosphate 3-kinase (IP3K). The IP3K modulators can be further examined for their activity in modulating development of progenitor T cells (e.g., CD4/CD8double positive T cells) into mature CD4or CD8single positive T cells. Pharmaceutical compositions comprising these T cell modulators can be administered to a subject to modulate T cell immune responses, to suppress inflammations, and to treat disease conditions such as autoimmune diseases, graft rejection or allergies.